2. GPCR/G Protein
  3. ICMT
  4. ICMT-IN-35

ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines.

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ICMT-IN-35

ICMT-IN-35 Estructura química

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ICMT-IN-35 Related Antibodies

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Descripciòn

ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines[1].

IC50 & Target

IC50: 0.8 μM (ICMT)[1]
Peso molecular

435.58

Fòrmula

C25H29N3O2S
SMILES

C/C(CCN(N=N1)C=C1CCC(C=C2)=CC=C2C3=CC=CC=C3)=C/SCCC(OC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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ICMT-IN-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICMT-IN-35ICMTIsoprenylcysteine carboxyl methyltransferaseMelanomacancer cell metastasiscell proliferationRAS membrane localizationmislocalizationisoprenylcysteine carboxyl methyltransferaseInhibitorinhibitorinhibit

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Nombre del producto:
ICMT-IN-35
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HY-149709
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