BM635
Based on 1 Customer Validation
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv.
For research use only. We do not sell to patients.
- Purity : 98.06%
- CAS No.: 1493762-74-5
- Formula: C25H29FN2O
- Molecular Weight:392.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
MIC50: 0.12 μM (M. tuberculosis H37Rv)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
40 μM
Compound: BM635
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Cytotoxicity against human HepG2 cells incubated for 48 hrs by CellTiter Glo assay
Cytotoxicity against human HepG2 cells incubated for 48 hrs by CellTiter Glo assay
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[PMID: 31620228] |
| HepG2 | IC50 |
15.3 μM
Compound: I
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Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay
Cytotoxicity against human HepG2 cells after 48 hrs by CellTiter-Glo assay
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[PMID: 28778369] |
| Vero | IC50 |
50.15 μM
Compound: I
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Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 28778369] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1493762-74-5
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Appearance Solid
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Molecular Weight 392.51
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Formula C25H29FN2O
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Color White to off-white
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SMILES
CC(C1=CC=C(C2=CC(CN3CCOCC3)=C(C)N2C4=CC=C(F)C=C4)C=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 31 mg/mL (78.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Poce G, et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2):e56980. [Content Brief]
[2]. Poce G, et al. Pharmaceutical salt of BM635 with improved bioavailability. Eur J Pharm Sci. 2017 Mar 1;99:17-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5477 mL | 12.7385 mL | 25.4771 mL | 63.6926 mL |
| 5 mM | 0.5095 mL | 2.5477 mL | 5.0954 mL | 12.7385 mL | |
| 10 mM | 0.2548 mL | 1.2739 mL | 2.5477 mL | 6.3693 mL | |
| 15 mM | 0.1698 mL | 0.8492 mL | 1.6985 mL | 4.2462 mL | |
| 20 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1846 mL | |
| 25 mM | 0.1019 mL | 0.5095 mL | 1.0191 mL | 2.5477 mL | |
| 30 mM | 0.0849 mL | 0.4246 mL | 0.8492 mL | 2.1231 mL | |
| 40 mM | 0.0637 mL | 0.3185 mL | 0.6369 mL | 1.5923 mL | |
| 50 mM | 0.0510 mL | 0.2548 mL | 0.5095 mL | 1.2739 mL | |
| 60 mM | 0.0425 mL | 0.2123 mL | 0.4246 mL | 1.0615 mL |
BM635 Related Classifications
HY-109587 Related Classifications
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