1. Anti-infection
  2. Bacterial
  3. BM635 mesylate

BM635 mesylate 

Cat. No.: HY-109587B
Handling Instructions

BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC50 of 0.6 μM against M. tuberculosis  H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635.

For research use only. We do not sell to patients.

BM635 mesylate Chemical Structure

BM635 mesylate Chemical Structure

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Description

BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC50 of 0.6 μM against M. tuberculosis  H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635[1].

IC50 & Target

MIC50: 0.08 μM (M. tuberculosis H37Rv)[1]

In Vivo

BM635 mesylate (oral administration; 50 mg/kg) results in gradual elevations in blood up to a Cmax of 2970 ng/ml with Tmax of 0.8 hour, it has a improved solubility compared to BM635 hydrochloride. In addition, BM635-Mes significantly improves the bioavailability with a AUC 4 times higher than free-base BM635[1].

Molecular Weight

488.61

Formula

C₂₆H₃₃FN₂O₄S

SMILES

CC(C1=CC=C(C2=CC(CN3CCOCC3)=C(C)N2C4=CC=C(F)C=C4)C=C1)C.OS(=O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BM635BM 635BM-635Bacterialanti-mycobacterialM.tuberculosisMycobacteriumInhibitorinhibitorinhibit

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Product name:
BM635 mesylate
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HY-109587B
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