NUBP1 - NUBP iron-sulfur cluster assembly factor 1, cytosolic Gene

Also Known as NBP; NBP1; CIAO5; NBP35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4682

About NUBP1

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:10,743,842-10,769,351 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 9.0), heart (RPKM 8.6) and 25 other tissues.

Summary

NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]

NUBP1 Products (6)

mRNA	Protein	Name
NM_001278506.2	NP_001265435.1	cytosolic Fe-S cluster assembly factor NUBP1 isoform 2
NM_001323594.2	NP_001310523.1	cytosolic Fe-S cluster assembly factor NUBP1 isoform 3
NM_001323595.2	NP_001310524.1	cytosolic Fe-S cluster assembly factor NUBP1 isoform 4
NM_001323596.2	NP_001310525.1	cytosolic Fe-S cluster assembly factor NUBP1 isoform 5
NM_001323597.1	NP_001310526.1	cytosolic Fe-S cluster assembly factor NUBP1 isoform 6
NM_002484.4	NP_002475.2	cytosolic Fe-S cluster assembly factor NUBP1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables iron-sulfur cluster binding	IDA IDA: Inferred from direct assay	18573874	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18573874	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	18573874	GOA
involved in iron-sulfur cluster assembly	IMP IMP: Inferred from mutant phenotype	18573874	GOA
involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18573874	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	18573874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUBP1 Protein Structure

ArsA_ATPase

ParA

0
100
200
300
320 a.a.

Protein Preferred Names	Protein Names
cytosolic Fe-S cluster assembly factor NUBP1	NBP 1

NUBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUBP1	P53384	NUBP2	Homo sapiens	Q9Y5Y2	Anti Tag CoIP	18573874

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pica Disease	Pica
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6	Mitochondrial Dna Deletion Syndrome With Progressive Myopathy PEOA6 Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 6 Dna2-Related Mitochondrial Dna Deletion Syndrome Mitochondrial Dna Deletion Syndrome With Limb-Girdle Weakness Mtdna Deletion Syndrome With Limb-Girdle Weakness Mtdna Deletion Syndrome With Progressive Myopathy Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 6 Progressive External Ophthalmoplegia, Autosomal Dominant 6 Autosomal Dominant Progressive External Ophthalmoplegia 6 Progressive External Ophthalmoplegia Autosomal Dominant 6 Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09651	NUBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09652	NUBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NUBP1	VGNC	VGNC:44017
Felis catus	NUBP1	VGNC	VGNC:68584
Macaca mulatta	NUBP1	VGNC	VGNC:75546
Rattus norvegicus	NUBP1	RGD	RGD:1310514
Bos taurus	NUBP1	VGNC	VGNC:32315
Mus musculus	NUBP1	MGD	MGI:1347073
Others	NUBP1	NCBI