IDO1-IN-7
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2351199-98-7
- Formula: C22H19ClFN3O3
- Molecular Weight:427.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 6.1 nM (IDO1, SKOV3 cells)[1]
In Vitro
IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC50of 330 nM[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC50=14,000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse[1]
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Dosage:10 mg/kg (Pharmacokinetic Analysis)
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Administration:Oral administration
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Result:Cmax (10.0 µM), AUC0-8 h (27.1 µM*h), t1/2 (1.4 h)
Chemical Information
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CAS No. 2351199-98-7
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Molecular Weight 427.86
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Formula C22H19ClFN3O3
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SMILES
FC1=CC2=C(C=C1)N=CC=C2[C@@H](CC3)[C@@H](O)CN3C(C(NC4=CC=C(Cl)C=C4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDO1-IN-7 Related Classifications
HY-134583 Related Classifications
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