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Cat. No.: HY-160254

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1954U89

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 150057-49-1
Formula: C₁₆H₂₁N₅
Molecular Weight:283.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

1954U89 Chemical Structure

CAS No.: 150057-49-1

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.8 nM Compound: 5o	Cytotoxic Activity was evaluated against 143B (TK-) tumor cells Cytotoxic Activity was evaluated against 143B (TK-) tumor cells	[PMID: 8632413]
A549	IC₅₀	0.4 nM Compound: 5o	Cytotoxic activity evaluated against A549 tumor cells Cytotoxic activity evaluated against A549 tumor cells	[PMID: 8632413]
Daoy	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against Daoy tumor cells Cytotoxic activity was evaluated against Daoy tumor cells	[PMID: 8632413]
HCT-8	IC₅₀	0.74 nM Compound: 5o	Activity was evaluated against HCT-8 tumor cells Activity was evaluated against HCT-8 tumor cells	[PMID: 8632413]
NCI-H460	IC₅₀	0.5 nM Compound: 5o	Cytotoxic Activity was evaluated against H460 tumor cells Cytotoxic Activity was evaluated against H460 tumor cells	[PMID: 8632413]
P388	IC₅₀	0.12 nM Compound: 5o	Cytotoxic activity was evaluated against P388D1 tumor cells Cytotoxic activity was evaluated against P388D1 tumor cells	[PMID: 8632413]
U-373MG ATCC	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against U373MG tumor cells Cytotoxic activity was evaluated against U373MG tumor cells	[PMID: 8632413]
U-87MG ATCC	IC₅₀	2.1 nM Compound: 5o	Cytotoxic activity was evaluated against U87MG tumor cells Cytotoxic activity was evaluated against U87MG tumor cells	[PMID: 8632413]
Vero	IC₅₀	1 nM Compound: 5o	Cytotoxic Activity was evaluated against Vero tumor cells Cytotoxic Activity was evaluated against Vero tumor cells	[PMID: 8632413]

Chemical Information

CAS No. 150057-49-1
Molecular Weight 283.37
Formula C₁₆H₂₁N₅
SMILES

CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42. [Content Brief]

[2]. Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24(11): 1531-1537.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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