Gymnopusin
Gymnopusin is an L-type voltage-dependent calcium channel blocker and vasorelaxant. Gymnopusin inhibits KCl- and Norepinephrine-induced contractility as well as CaCl2-induced contractions. Gymnopusin induces endothelium-independent relaxation involving the opening of ATP-sensitive and calcium-activated potassium channels. Gymnopusin disrupts membranes through tonoplast lysis, leading to electrolyte leakage, chlorophyll loss, and photobleaching in duckweed. Gymnopusin inhibits radicle elongation in Amaranthus hypochondriacus seedlings and exhibits phytotoxicity against duckweed. Gymnopusin shows moderate cytotoxicity against mammalian cell lines. Gymnopusin can be used for research on hypertension.
For research use only. We do not sell to patients.
- CAS No.: 113476-61-2
- Formula: C17H16O5
- Molecular Weight:300.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
In Vitro
Gymnopusin induces relaxation of rat aortic rings pre-contracted with Norepinephrine (NE) (HY-13715) in a concentration-dependent and endothelium-independent manner, with an EC50 of 63 μM in endothelium-intact rings[1].
Gymnopusin induces relaxation of endothelium-denuded rat aortic rings pre-contracted with KCl (80 mM), with an EC50 of 119 μM[1].
In endothelium-denuded rat aortic rings, the vasodilatory mechanism of Gymnopusin involves the opening of K+ channels[1].
Gymnopusin (49-63 μM; 15 min) inhibits NE-induced contraction in endothelium-denuded rat aortic rings in a non-parallel manner[1].
Gymnopusin (11-63 μM; 15 min) inhibits CaCl2-induced contraction in endothelium-denuded rat aortic rings, indicating Ca2+ entry blocking activity[1].
Gymnopusin (11-63 μM; 15 min) blocks L-type voltage-gated Ca2+ channels in endothelium-denuded rat aortic rings[1].
Gymnopusin (10-1000 μg/mL) inhibits radicle elongation in Amaranthus hypochondriacus seedlings with an IC50 of 330 μM[2].
Gymnopusin (25-200 μM; 72 h) causes electrolyte leakage, growth inhibition, and chlorophyll reduction in Lemna pausicostata cultures[2].
Gymnopusin (100 μM; 12-72 h) causes membrane rupture in Lemna pausicostata frond tissue, and transmission electron microscopy reveals tonoplast rupture, organelle release, and liposomes[2].
Gymnopusin (100 μM; 72 h) causes root cap loss, increased vacuolization, and the appearance of large starch grains within the chloroplast stroma in root tissues of Lemna pausicostata[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 113476-61-2
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Molecular Weight 300.31
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Formula C17H16O5
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SMILES
OC(C=CC1=C2C(OC)=C(OC)C(O)=CC2=C3)=CC1=C3OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gymnopusin Related Classifications
HY-187605 Related Classifications
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Keywords
- Gymnopusin
- 113476-61-2
- Calcium Channel
- L-type voltage-dependent calcium channel blocker
- radicle elongation
- calcium-activated potassium channel opening
- ATP-sensitive
- rat aortic rings
- vasorelaxant
- Amaranthus hypochondriacus
- endothelium-independent relaxation
- Lemna pausicostata
- tonoplast lysis
- Inhibitor
- inhibitor
- inhibit