2. Immunology/Inflammation
  3. NO Synthase
  4. iNOS-IN-2

iNOS-IN-2 (Compound 53) is a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. iNOS-IN-2 effectively inhibits the NO production (IC50=6.4 μM). iNOS-IN-2 has a potential therapeutic effect on chronic inflammation.

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iNOS-IN-2

iNOS-IN-2 Chemische Struktur

CAS. Nr. : 2419891-42-0

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iNOS-IN-2 Related Antibodies

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Beschreibung

iNOS-IN-2 (Compound 53) is a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. iNOS-IN-2 effectively inhibits the NO production (IC50=6.4 μM). iNOS-IN-2 has a potential therapeutic effect on chronic inflammation[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
>80 μM
Compound: 53
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 32208222]
RAW264.7 IC50
6.4 μM
Compound: 53
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
[PMID: 32208222]
Molekulargewicht

457.52

Formel

C25H31NO7
CAS. Nr.
SMILES

O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(OCCCN3CCOCC3)C(OC)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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iNOS-IN-2 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOS-IN-22419891-42-0NO SynthaseNitric oxide synthasesNOSInflammationNitric oxideNOInducible nitric oxide synthaseiNOSInhibitorinhibitorinhibit

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