2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. IQM-266

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a KD of 4.63 μM. IQM-266 inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD).

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IQM-266

IQM-266 Chemical Structure

CAS No. : 1956337-58-8

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Based on 1 publication(s) in Google Scholar

IQM-266 Related Antibodies

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Description

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a KD of 4.63 μM. IQM-266 inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD)[1].

In Vitro

IQM-266 (0-100 μM) concentration-dependently inhibits Kv4.3/DREAM channels (IC50 = 8.6 μM) in CHO cells by slowing their activation and inactivation kinetics[1].
IQM-266 (0-100 μM) inhibits the maximum peak current and, to a lesser extent, the charge crossing the cell membrane during depolarization at ≥ 10 μM in CHO cells[1].
IQM-266 (3 μM) increases the charge through the cell membrane during the application of depolarizing pulses, and inhibits peak Kv4.3/DREAM current amplitude while slowing its inactivation in CHO cells[1].
IQM-266 (3-10 μM) slows the recovery process and increases closed-state inactivation of Kv4.3/DREAM channels in a concentration-dependent manner in CHO cells through its specific interaction with DREAM, which also underlies the observed increase in transmembrane charge[1].
IQM-266 (3-10 μM) dose-dependently reduces the peak amplitude of IA in rat DRG neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IQM-266 Related Antibodies
Molecular Weight

397.42

Formula

C25H19NO4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC(C=CC=C2)=C2C=C1C(O)=O)CC3=CC(OC4=CC=CC=C4)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (251.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5162 mL 12.5811 mL 25.1623 mL
5 mM 0.5032 mL 2.5162 mL 5.0325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5162 mL 12.5811 mL 25.1623 mL 62.9057 mL
5 mM 0.5032 mL 2.5162 mL 5.0325 mL 12.5811 mL
10 mM 0.2516 mL 1.2581 mL 2.5162 mL 6.2906 mL
15 mM 0.1677 mL 0.8387 mL 1.6775 mL 4.1937 mL
20 mM 0.1258 mL 0.6291 mL 1.2581 mL 3.1453 mL
25 mM 0.1006 mL 0.5032 mL 1.0065 mL 2.5162 mL
30 mM 0.0839 mL 0.4194 mL 0.8387 mL 2.0969 mL
40 mM 0.0629 mL 0.3145 mL 0.6291 mL 1.5726 mL
50 mM 0.0503 mL 0.2516 mL 0.5032 mL 1.2581 mL
60 mM 0.0419 mL 0.2097 mL 0.4194 mL 1.0484 mL
80 mM 0.0315 mL 0.1573 mL 0.3145 mL 0.7863 mL
100 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.6291 mL
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IQM-266 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQM-2661956337-58-8IQM266IQM 266Potassium ChannelKcsADREAMKV4.3DRG neuronsneurological diseaseAlzheimerHuntingtonInhibitorinhibitorinhibit

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