IRDye700Dx (Maleimide)
IRDye700Dx Maleimide is a Photosensitizer. When conjugated with HER2 Affibody and activated by near-infrared light, IRDye700Dx Maleimide induces death in HER2-positive breast cancer cells without causing damage to HER2-negative breast cancer cells.
For research use only. We do not sell to patients.
- Formula: C76H99N13Na4O26S6Si3
- Molecular Weight:1979.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Incubation of HER2 Affibody with IRDye700Dx Maleimide (5-fold molar excess; 2 h) successfully yields purified HER2 Affibody-IR700Dye conjugates[1].
HER2 Affibody-IR700Dye conjugate (0.1-0.3 μM; 2 h) induces selective cytotoxicity in HER2-positive SK-BR3, MDA-MB361 and JIMT1 breast cancer cells, but exerts no such effect in HER2-negative MCF7 breast cancer cells when used for near-infrared photoimmunotherapy (NIR-PIT)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1979.28
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Formula C76H99N13Na4O26S6Si3
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SMILES
C[Si](CCC[N+](CCC[S](=O)(O[Na])=O)(CCC[S](=O)(O[Na])=O)CCC[S](=O)([O-])=O)(C)[O-][Si+4]12([N-]3C4=NC(C5=CC=CC=C65)=[N]1C6=NC7=C(C=CC=C8)C8=C9[N-]27)([N](C%10=N9)=C(C%11=CC=CC=C%10%11)N=C3C%12=CC=CC(OCCCOC(NCCCCCC(NCCN%13C(C=CC%13=O)=O)=O)=O)=C4%12)[O-][Si](C)(C)CCC[N+](CCC[S](=O)(O[Na])=O)(CCC[S](=O)(O[Na])=O)CCC[S](=O)([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IRDye700Dx (Maleimide) Related Classifications
HY-D2309 Related Classifications
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- IRDye700Dx (Maleimide)
- Fluorescent Dye
- Photosensitizer
- brain metastatic breast cancer cells
- mouse models
- HER2 low-expressing breast cancer cells
- HER2-positive breast cancer cells
- HER2 Affibody
- trastuzumab-resistant breast cancer cells
- HER2-negative breast cancer cells
- SK-BR3 breast cancer cells
- near-infrared light
- trastuzumab
- Inhibitor
- inhibitor
- inhibit