Isopropyl myristate
Based on 1 Customer Validation
Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate is used for transdermal delivery of some compounds. Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 110-27-0
- Formula: C17H34O2
- Molecular Weight:270.45
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isopropyl myristate (5%) and Isopropyl alcohol (HY-Y0593) have synergistic effects on the microstructure of human stratum corneum[2].
Isopropyl myristate and Glyceryl monocaprylate (HY-138650) have synergistic effects on the skin Permeation of pentazocine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 110-27-0
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Appearance Liquid (Density: 0.85 g/cm3 )
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Molecular Weight 270.45
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Formula C17H34O2
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Color Colorless to light yellow
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SMILES
CCCCCCCCCCCCCC(OC(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (369.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.24 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[2]. Brinkmann I, et al. Role of isopropyl myristate, isopropyl alcohol and a combination of both in hydrocortisone permeation across the human stratum corneum. Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):393-404. [Content Brief]
[3]. Furuishi T, et al. Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine. Biol Pharm Bull. 2010;33(2):294-300. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.6975 mL | 18.4877 mL | 36.9754 mL | 92.4385 mL |
| 5 mM | 0.7395 mL | 3.6975 mL | 7.3951 mL | 18.4877 mL | |
| 10 mM | 0.3698 mL | 1.8488 mL | 3.6975 mL | 9.2439 mL | |
| 15 mM | 0.2465 mL | 1.2325 mL | 2.4650 mL | 6.1626 mL | |
| 20 mM | 0.1849 mL | 0.9244 mL | 1.8488 mL | 4.6219 mL | |
| 25 mM | 0.1479 mL | 0.7395 mL | 1.4790 mL | 3.6975 mL | |
| 30 mM | 0.1233 mL | 0.6163 mL | 1.2325 mL | 3.0813 mL | |
| 40 mM | 0.0924 mL | 0.4622 mL | 0.9244 mL | 2.3110 mL | |
| 50 mM | 0.0740 mL | 0.3698 mL | 0.7395 mL | 1.8488 mL | |
| 60 mM | 0.0616 mL | 0.3081 mL | 0.6163 mL | 1.5406 mL | |
| 80 mM | 0.0462 mL | 0.2311 mL | 0.4622 mL | 1.1555 mL | |
| 100 mM | 0.0370 mL | 0.1849 mL | 0.3698 mL | 0.9244 mL |
Isopropyl myristate Related Classifications
HY-124190 Related Classifications
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