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Cat. No.: HY-P12360

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4T1pep1

4T1pep1 is a tumor-homing cyclic peptide obtained through phage display screening. 4T1pep1 binds to mouse 4T1 triple-negative breast cancer cells and human MDA-MB-231 triple-negative breast cancer cells. 4T1pep1 is useful for triple-negative breast cancer-related research.

For research use only. We do not sell to patients.

Formula: C₃₂H₅₄N₁₀O₁₅S₂
Molecular Weight:882.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

4T1pep1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

4T1pep1 exhibits high binding affinity and selectivity for 4T1 cells, and it also binds to human MDA-MB-231 cells, while showing no affinity for control 3T3 cells; its potential target is Mucin-16^[1].
4T1pep1 is a novel peptide ligand identified against a mouse triple-negative breast cancer cell line through in vitro phage display biopanning, and it holds potential for nano-targeted delivery in TNBC therapy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 882.96
Formula C₃₂H₅₄N₁₀O₁₅S₂
Sequence

Cys-Pro-Thr-Ala-Ser-Asn-Thr-Ser-Cys
Sequence Shortening

CPTASNTSC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Silva V L, et al. Selection of Novel Peptides Homing the 4T1 CELL Line: Exploring Alternative Targets for Triple Negative Breast Cancer. PLOS ONE, 2016, 11(8): e0161290.

[2]. Abbaszadeh F. Bacteriophages: cancer diagnosis, treatment, and future prospects. Journal of Pharmaceutical Investigation. 2021 Jan;51(1):23-34.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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