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Cat. No.: HY-112300

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ERK2 IN-1

ERK2 IN-1 is a selective ERK2 inhibitor with an IC₅₀ of 7 nM.

For research use only. We do not sell to patients.

CAS No.: 1093061-47-2
Formula: C₃₆H₃₄FN₇O₂S
Molecular Weight:647.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ERK2 IN-1 Chemical Structure

CAS No.: 1093061-47-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

ERK2 IN-1 is a selective ERK2 inhibitor with an IC₅₀ of 7 nM^[1].

IC₅₀ & Target^[1]

ERK2

7 nM (IC₅₀)

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	45 nM Compound: 7	Antiproliferative activity against human COLO205 cells harboring BRAF V600E/D mutant measured after 4 days Antiproliferative activity against human COLO205 cells harboring BRAF V600E/D mutant measured after 4 days	[PMID: 30034615]
HT-29	IC₅₀	118 nM Compound: 7	Antiproliferative activity against human HT-29 cells harboring BRAF V600E/D mutant measured after 4 days Antiproliferative activity against human HT-29 cells harboring BRAF V600E/D mutant measured after 4 days	[PMID: 30034615]
HT-29	IC₅₀	118 nM Compound: 28	Antiproliferative activity against human HT-29 cells harboring BRAF/KRAS mutant Antiproliferative activity against human HT-29 cells harboring BRAF/KRAS mutant	[PMID: 29748051]
HT-29	IC₅₀	80 nM Compound: 28	Induction of apoptosis in human HT-29 cells harboring BRAF/KRAS mutant by caspase activation assay Induction of apoptosis in human HT-29 cells harboring BRAF/KRAS mutant by caspase activation assay	[PMID: 29748051]

In Vitro

ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC₅₀=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC₅₀=118/80 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1093061-47-2
Molecular Weight 647.76
Formula C₃₆H₃₄FN₇O₂S
SMILES

FC1=CC=C(C2=NNC3=C2C=C(NC([C@@]4(SC)CN(CC(N5CCC(C6=CC=C(C7=NC=CC=N7)C=C6)=CC5)=O)CC4)=O)C=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Boga SB, Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ERK2 IN-1

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ERK2 IN-1 Related Classifications

HY-112300 Related Classifications