ERK2 IN-1
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
For research use only. We do not sell to patients.
- CAS No.: 1093061-47-2
- Formula: C36H34FN7O2S
- Molecular Weight:647.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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ERK1/2 inhibitor 1ERK1/2 Inhibitor
Biological Activity
Description
IC50 & Target
[1]|
ERK2 7 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
45 nM
Compound: 7
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Antiproliferative activity against human COLO205 cells harboring BRAF V600E/D mutant measured after 4 days
Antiproliferative activity against human COLO205 cells harboring BRAF V600E/D mutant measured after 4 days
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[PMID: 30034615] |
| HT-29 | IC50 |
118 nM
Compound: 7
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Antiproliferative activity against human HT-29 cells harboring BRAF V600E/D mutant measured after 4 days
Antiproliferative activity against human HT-29 cells harboring BRAF V600E/D mutant measured after 4 days
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[PMID: 30034615] |
| HT-29 | IC50 |
118 nM
Compound: 28
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Antiproliferative activity against human HT-29 cells harboring BRAF/KRAS mutant
Antiproliferative activity against human HT-29 cells harboring BRAF/KRAS mutant
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[PMID: 29748051] |
| HT-29 | IC50 |
80 nM
Compound: 28
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Induction of apoptosis in human HT-29 cells harboring BRAF/KRAS mutant by caspase activation assay
Induction of apoptosis in human HT-29 cells harboring BRAF/KRAS mutant by caspase activation assay
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[PMID: 29748051] |
In Vitro
ERK1/2 IN-1 (Compound 28) maintains good ERK enzymatic activity (ERK IC50=7 nM) and cellular activity in BRAF/KRAS mutant wildtype cancer cell lines (HT-29/Caspase IC50=118/80 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1093061-47-2
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Molecular Weight 647.76
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Formula C36H34FN7O2S
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SMILES
FC1=CC=C(C2=NNC3=C2C=C(NC([C@@]4(SC)CN(CC(N5CCC(C6=CC=C(C7=NC=CC=N7)C=C6)=CC5)=O)CC4)=O)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK2 IN-1 Related Classifications
HY-112300 Related Classifications
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