Dimethyl sulfoxide
(Synonyms: DMSO)
34 Cited Publications
Customer Review
Based on 34 publication(s) in Google Scholar
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity.
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 67-68-5
- Formula: C2H6OS
- Molecular Weight:78.13
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Storage:
Store at room temperature, keep dry and cool
Size
Price
Stock
Quantity
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dimethyl sulfoxide
More- Adv Sci (Weinh). 2026 May;13(25):e15933. [Abstract]
- Engineering. 2025 Nov 14.
- J Transl Med. 2025 Nov 12;23(1):1271. [Abstract]
- Cell Chem Biol. 2026 Mar 19;33(3):307-320.e4. [Abstract]
- Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]
- Br J Cancer. 2025 Sep;133(5):697-708. [Abstract]
- J Agric Food Res. 2025 Oct 27;24:102486.
- Antioxid Redox Signal. 2025 Dec 26. [Abstract]
- Biochem Pharmacol. 2026 May:247:117796. [Abstract]
- Biochem Pharmacol. 2026 Apr:246:117708. [Abstract]
- Chem Biol Interact. 2025 Sep 20:111749. [Abstract]
- Microchem J. 2025 Nov 3;219:116046.
- CNS Neurosci Ther. 2026 Feb;32(2):e70777. [Abstract]
- CNS Neurosci Ther. 2025 Dec;31(12):e70661. [Abstract]
- Int Immunopharmacol. 2025 May 7:157:114764. [Abstract]
- Antimicrob Agents Chemother. 2025 Apr 14:e0189224. [Abstract]
- Comp Biochem Physiol C Toxicol Pharmacol. 2026 Jul:305:110517. [Abstract]
- Oncol Res. 2026 Jan 19;34(2):25. [Abstract]
- iScience. 2025 Nov 21;28(12):114175. [Abstract]
- Sci Rep. 2025 Dec 11. [Abstract]
- Brain Res Bull. 2025 Aug 24:230:111523. [Abstract]
- Mol Cell Biochem. 2025 Jun 11. [Abstract]
- J Hepatocell Carcinoma. 2025 Dec 24:12:2971-2988. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2026 Jan 28. [Abstract]
- Front Biosci (Landmark Ed). 2025 Jun 25;30(6):37052. [Abstract]
- Curr Issues Mol Biol. 2025 May 14;47(5):361. [Abstract]
- Acta Diabetol. 2025 May 12. [Abstract]
- Vet Microbiol. 2026 Feb:313:110871. [Abstract]
- J Integr Neurosci. 2025 Aug 21;24(8):39532. [Abstract]
- J Integr Neurosci. 2025 Aug 22;24(8):39286. [Abstract]
- Biochem Biophys Res Commun. 2026 Mar 12:804:153353. [Abstract]
- SSRN. 2026 Mar 19.
- Res Sq. 2026 Feb 10.
- bioRxiv. 2025 Sep 21.
Biological Activity
Description
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1].
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
Low endotoxin, can be used in various biochemical experiments such as drug dissolution.
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythroleukemia cell line | IC50 |
280 mM
Compound: DMSO
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Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
Anticancer activity against mouse Erythroleukemia cell line assessed as inhibition of cell growth
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[PMID: 34591474] |
| HEK293 | IC50 |
232 μM
Compound: DMSO
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Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
| HL-60 | IC50 |
108 μM
Compound: DMSO
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Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
| LN-18 | IC50 |
223 μM
Compound: DMSO
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Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
|
[PMID: 27108400] |
| MDCK-II | GI50 |
123 μM
Compound: DMSO
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Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
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[PMID: 32787102] |
| MDCK-II | GI50 |
137 μM
Compound: DMSO
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Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
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[PMID: 32787102] |
| THP-1 | IC50 |
119 μM
Compound: DMSO
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Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
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[PMID: 27108400] |
In Vitro
Dimethyl sulfoxide (DMSO) is a colorless liquid. Dimethyl sulfoxide is a polar, aprotic solvent miscible with water and able to dissolve an enormous catalog of polar and nonpolar small molecules.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 67-68-5
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Appearance Liquid (Density: 1.1 g/cm3)
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Molecular Weight 78.13
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Formula C2H6OS
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Color Colorless to light yellow
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SMILES
O=S(C)C
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Synonyms
DMSO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
Publications (34)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [Abstract]2026 May;13(25):e15933. PMID: 41732887 -
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J Transl Med
Retinal ALKBH5 inhibition induces myopia protection through selective regulation of ERK1/2 signaling. [Abstract]2025 Nov 12;23(1):1271. PMID: 41225555 -
Cell Chem Biol
2026 Mar 19;33(3):307-320.e4. PMID: 41650963 -
Cell Death Discov
Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis. [Abstract]2025 Nov 7;11(1):511. PMID: 41203627 -
Br J Cancer
New mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity. [Abstract]2025 Sep;133(5):697-708. PMID: 40588513 -
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Antioxid Redox Signal
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]2025 Dec 26. PMID: 41468154 -
Biochem Pharmacol
Mutant NPM1-regulated estrogen signaling promotes leukemia cell survival by upregulating HGF and represents a therapeutic vulnerability. [Abstract]2026 May:247:117796. PMID: 41679667 -
Biochem Pharmacol
Arachidonic acid analog AACOCF3 suppresses cPLA2-negative NSCLC cell proliferation by targeting SSRP1 to activate the IFNα/β pathway. [Abstract]2026 Apr:246:117708. PMID: 41544858 -
Chem Biol Interact
Phytosphingosine suppresses gastric cancer through SFRP4/β-catenin axis-mediated Wnt signaling pathway inhibition. [Abstract]2025 Sep 20:111749. PMID: 40983245 -
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CNS Neurosci Ther
TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury. [Abstract]2026 Feb;32(2):e70777. PMID: 41660680 -
CNS Neurosci Ther
Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 Pathway. [Abstract]2025 Dec;31(12):e70661. PMID: 41378869 -
Int Immunopharmacol
Andrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways. [Abstract]2025 May 7:157:114764. PMID: 40339493 -
Antimicrob Agents Chemother
Impact of hepatic impairment and renal failure on the pharmacokinetics of linezolid and its metabolites: contribution of hepatic metabolism and renal excretion. [Abstract]2025 Apr 14:e0189224. PMID: 40227039 -
Comp Biochem Physiol C Toxicol Pharmacol
Inactivation of the AMPKα/CncC/GPX4 axis mediates rotenone-induced ferroptosis in the silkworm (Bombyx mori) model. [Abstract]2026 Jul:305:110517. PMID: 41887387 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
iScience
A translational study on the survival and molecular mechanism of PD-L1 expression in EGFR-mutant NSCLC treated with osimertinib. [Abstract]2025 Nov 21;28(12):114175. PMID: 41446744 -
Sci Rep
Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathway. [Abstract]2025 Dec 11. PMID: 41381837 -
Brain Res Bull
Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption. [Abstract]2025 Aug 24:230:111523. PMID: 40858194 -
Mol Cell Biochem
FOXM1 upregulation, promotes immune escape in gastric cancer through activation of Notch signaling pathway. [Abstract]2025 Jun 11. PMID: 40498401 -
J Hepatocell Carcinoma
Integrated Transcriptomic Analysis Leveraging Single-Cell and Bulk RNA Sequencing Data to Uncover Pyroptosis-Related Prognostic Signatures in HCC. [Abstract]2025 Dec 24:12:2971-2988. PMID: 41467099 -
Naunyn Schmiedebergs Arch Pharmacol
Network pharmacology and experimental validation to explore the effects and mechanisms of flavonoids luteolin and chrysoeriol against non‑small cell lung cancer. [Abstract]2026 Jan 28. PMID: 41603923 -
Front Biosci (Landmark Ed)
2025 Jun 25;30(6):37052. PMID: 40613298 -
Curr Issues Mol Biol
2025 May 14;47(5):361. PMID: 40699760 -
Acta Diabetol
Dapagliflozin ameliorates metabolic and hepatic outcomes in a mouse model of metabolic dysfunction-associated steatotic liver disease and diabetes. [Abstract]2025 May 12. PMID: 40353918 -
Vet Microbiol
Phosphorylation of T425 and methylation of R426 synergistically regulate IBDV VP1 function and viral replication. [Abstract]2026 Feb:313:110871. PMID: 41506171 -
J Integr Neurosci
Glucocorticoid Alleviates Stress-induced Hypothalamic Nerve Injury by Inhibiting the GSDMD-dependent Pyroptosis Pathway. [Abstract]2025 Aug 21;24(8):39532. PMID: 40919628 -
J Integr Neurosci
Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice. [Abstract]2025 Aug 22;24(8):39286. PMID: 40919625 -
Biochem Biophys Res Commun
Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway. [Abstract]2026 Mar 12:804:153353. PMID: 41619504 -
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Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
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