FAAH-IN-5
FAAH-IN-5 is a dual FAAH/MAGL inhibitor with IC50 values of 0.0105 μM and 0.284 μM, respectively. FAAH-IN-5 shows reduced PAMPA permeability. FAAH-IN-5 produces near-complete blockade of TAMRA-FP labeling of human FAAH and MAGL, and produces significant blockade in homogenates. FAAH-IN-5 can be used in research related to FAAH-mediated diseases.
For research use only. We do not sell to patients.
- CAS No.: 1338575-38-4
- Formula: C21H19N3O6S
- Molecular Weight:441.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 10.5 nM (FAAH), 283 nM (MAGL)[1]
In Vitro
FAAH-IN-5 exhibits a low artificial membrane permeability of 2.6 × 10−7 cm/s in PAMPA[1].
FAAH-IN-5 irreversibly inhibits human recombinant FAAH in a rapid dilution assay; it almost completely blocks TAMRA-FP labeling of human FAAH and MAGL, and significantly blocks labeling in rat eye homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1338575-38-4
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Molecular Weight 441.46
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Formula C21H19N3O6S
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SMILES
O=C(N1CCN(CC1)S(=O)(C2=CC=C3C=CC=CC3=C2)=O)OC4=CC=C(C=C4)[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAAH-IN-5 Related Classifications
HY-146341 Related Classifications
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