KIF20A - kinesin family member 20A Gene

Also Known as RCM6; MKLP2; RAB6KIFL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10112

About KIF20A

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,179,112-138,187,723 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 7.6), bone marrow (RPKM 5.2) and 14 other tissues.

Summary

Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]

KIF20A Products (1)

mRNA Protein Name
NM_005733.3 NP_005724.1 kinesin-like protein KIF20A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16431929 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12939256 GOA
Biological Process GO Annotation Evidence References Source
involved in microtubule bundle formation IDA
IDA: Inferred from direct assay
12939256 GOA
involved in midbody abscission IMP
IMP: Inferred from mutant phenotype
15843429 GOA
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
15843429 GOA
involved in regulation of cytokinesis IDA
IDA: Inferred from direct assay
12939256 GOA
Cellular Component GO Annotation Evidence References Source
located in midbody IDA
IDA: Inferred from direct assay
15843429 GOA
located in spindle IDA
IDA: Inferred from direct assay
12939256 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF20A Protein Structure

Kinesin

Kinesin: Kinesin motor domain (70 - 506)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF20A

  • GG10_2

KIF20A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KIF20A O95235 ATOSB Homo sapiens Q7L5A3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Restrictive, 6

  • RCM6

  • Cardiomyopathy, Familial Restrictive 6
Familial Isolated Restrictive Cardiomyopathy

  • Familial Or Idiopathic Restrictive Cardiomyopathy
Restrictive Cardiomyopathy

  • Familial Restrictive Cardiomyopathy

  • Cardiomyopathy, Restrictive

  • Cardiomyopathy, Constrictive

  • Primary Restrictive Cardiomyopathy

  • Rcm

  • Cardiomyopathy Restrictive
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07272 KIF20A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20561 Kif20a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27070 Kif20a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KIF20A VGNC VGNC:69205
Macaca mulatta KIF20A VGNC VGNC:74037
Bos taurus KIF20A VGNC VGNC:30594
Canis familiaris KIF20A VGNC VGNC:42394
Mus musculus KIF20A MGD MGI:1201682
Rattus norvegicus KIF20A RGD RGD:1307695
Others KIF20A NCBI