Dnase1 - deoxyribonuclease I Gene

Also Known as Dnl1; DNaseI

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13419

Summary

Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in cytoplasmic vesicle and extracellular region. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnase1 Products (2)

mRNA Protein Name
NM_001357143.1 NP_001344072.1 deoxyribonuclease-1 precursor
NM_010061.5 NP_034191.3 deoxyribonuclease-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables deoxyribonuclease I activity IMP
IMP: Inferred from mutant phenotype
15015938 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA catabolic process IDA
IDA: Inferred from direct assay
29191910 MGI
involved in neutrophil activation involved in immune response IDA
IDA: Inferred from direct assay
29191910 MGI
involved in regulation of acute inflammatory response IDA
IDA: Inferred from direct assay
29191910 MGI
involved in regulation of neutrophil mediated cytotoxicity IDA
IDA: Inferred from direct assay
29191910 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxyribonuclease-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145996 STC314 / Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03894 DNASE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03895 DNASE1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03896 DNASE1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03897 DNASE1L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18729 Dnase1l3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20150 Dnase1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25216 Dnase1l3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26654 Dnase1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnase1 NCBI NCBI:1773