Gap43 - growth associated protein 43 Gene

Also Known as Basp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29423

Summary

Enables lysophosphatidic acid binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in nervous system development; regulation of postsynaptic specialization assembly; and tissue regeneration. Located in cytoplasm. Is active in GABA-ergic synapse. Biomarker of visual epilepsy. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Apr 2022]

Gap43 Products (1)

mRNA Protein Name
NM_017195.3 NP_058891.1 neuromodulin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysophosphatidic acid binding IDA
IDA: Inferred from direct assay
17295609 RGD
enables phosphatidylinositol phosphate binding IDA
IDA: Inferred from direct assay
17295609 RGD
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
1826685 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
29476059 RGD
Biological Process GO Annotation Evidence References Source
involved in nervous system development IEP
IEP: Inferred from expression pattern
2437653 RGD
involved in regulation of postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
25755278 RGD
involved in regulation of postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
25755278 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
22428005 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
12597125 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25755278 RGD
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25755278 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
16203100 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuromodulin

  • axonal membrane protein GAP-43

  • brain abundant, membrane attached signal protein 2

  • growth accentuating protein 43

  • protein F1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129108 9-cis-UAB30 / Unkown
HY-161783 HDAC6-IN-45 / Unkown
HY-168857 GSK-3β inhibitor 24 / Unkown
HY-RS05272 GAP43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18821 Gap43 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25311 Gap43 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gap43 NCBI NCBI:2596