GAP43 - growth associated protein 43 Gene

Also Known as B-50; PP46; GAP-43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2596

About GAP43

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:115,623,510-115,721,483 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 2 paralogues. Biased expression in brain (RPKM 55.1) and appendix (RPKM 1.7).

Summary

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GAP43 Products (2)

mRNA	Protein	Name
NM_001130064.2	NP_001123536.1	neuromodulin isoform 1
NM_002045.4	NP_002036.1	neuromodulin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9139733	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in filopodium membrane	IDA IDA: Inferred from direct assay	14978216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAP43 Protein Structure

Neuromodulin_N

Neuromodulin

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
neuromodulin	axonal membrane protein GAP-43

GAP43 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GAP43	P17677	PRKCD	Homo sapiens	Q05655	Pull Down	9139733
Intra	GAP43	P17677	DRD4	Homo sapiens	P21917	Validated Y2H	32814053
Intra	GAP43	P17677	DRD4	Homo sapiens	P21917	Y2H Array	32814053
Intra	GAP43	P17677	DRD4	Homo sapiens	P21917	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GAP43 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75175	GAP43 Protein, Human (HEK293, His)	P17677-1 (M1-A238)	≥ 95%, as determined by reducing SDS-PAGE.

GAP43 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83146	GAP43 Antibody (YA2891)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P83146A	GAP43 Antibody (YA2891)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P85729	GAP43 Antibody (YA5421)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86401	GAP43 Antibody (YA6093)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86728	GAP43 Antibody (YA6420)	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Human, Mouse, Rat
HY-P86728A	GAP43 Antibody (YA6420)(PBS only)	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Cardiomyopathy, Dilated, 1m	Dilated Cardiomyopathy 1m CMD1M Cardiomyopathy, Dilated 1m Cardiomyopathy, Dilated, Type 1m
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Leukodystrophy, Hypomyelinating, 3	Hypomyelinating Leukodystrophy 3 HLD3 Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation Leukodystrophy, Hypomyelinating 3 Perinatal Sudanophilic Leukodystrophy Leukodystrophy, Hypomyelinating, Type 3 Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129108	9-cis-UAB30		/	Unkown
HY-161783	HDAC6-IN-45		/	Unkown
HY-168857	GSK-3β inhibitor 24		/	Unkown
HY-RS05272	GAP43 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18821	Gap43 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25311	Gap43 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GAP43	VGNC	VGNC:29247
Rattus norvegicus	GAP43	RGD	RGD:62071
Canis familiaris	GAP43	VGNC	VGNC:41108
Mus musculus	GAP43	MGD	MGI:95639
Macaca mulatta	GAP43	VGNC	VGNC:72880
Others	GAP43	NCBI