DMAC1 - distal membrane arm assembly component 1 Gene

Also Known as TMEM261; C9orf123

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90871

About DMAC1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:7,796,500-7,799,778 (from NCBI)

This gene has 3 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in heart (RPKM 8.9), kidney (RPKM 8.7) and 25 other tissues.

Summary

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Colocalizes with mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]

DMAC1 Products (3)

mRNA Protein Name
NM_001318058.2 NP_001304987.1 distal membrane-arm assembly complex protein 1 isoform 1
NM_001318059.2 NP_001304988.1 distal membrane-arm assembly complex protein 1 isoform 3
NM_033428.3 NP_219500.1 distal membrane-arm assembly complex protein 1 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27626371 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMAC1 Protein Structure

DUF4536

DUF4536: Domain of unknown function (DUF4536) (47 - 92)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

distal membrane-arm assembly complex protein 1

  • distal membrane arm assembly complex 1

Related Diseases

Diseases Alias
Hodgkin'S Lymphoma, Nodular Sclerosis

  • Classical Hodgkin Lymphoma, Nodular Sclerosis

  • Classic Hodgkin Lymphoma, Nodular Sclerosis Type

  • Nodular Sclerosis Hodgkin Lymphoma

  • Hodgkin'S Disease, Nodular Sclerosis

  • Hodgkin Disease, Nodular Sclerosis

  • Hodgkin Lymphoma, Nodular Sclerosis

  • Hodgkin Nodular Sclerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03818 DMAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22469 Dmac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28992 Dmac1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DMAC1 VGNC VGNC:102918
Rattus norvegicus DMAC1 RGD RGD:1309148
Canis familiaris DMAC1 VGNC VGNC:39993
Mus musculus DMAC1 MGD MGI:1914178
Bos taurus DMAC1 VGNC VGNC:28103
Others DMAC1 NCBI