Isothiafludine
Based on 1 Customer Validation
Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 960527-22-4
- Formula: C18H18FN3OS2
- Molecular Weight:375.48
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
29 μM
Compound: NZ-4; 10
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
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[PMID: 30594676] |
| HepG2 2.2.15 | CC50 |
50.4 μM
Compound: II-8c; NZ-4
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Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
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[PMID: 32712535] |
| HepG2 2.2.15 | CC50 |
51.47 μM
Compound: NZ-4
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Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
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[PMID: 27484509] |
| HepG2 2.2.15 | CC50 |
59.2 μM
Compound: II-8c; NZ-4
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Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
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[PMID: 32712535] |
| HepG2 2.2.15 | IC50 |
50.4 μM
Compound: NZ-4
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Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
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[PMID: 27484509] |
Isothiafludine inhibits HBV DNA replication, with an IC50 of 1.33 μM[1].
Isothiafludine (8 days) shows an IC50 (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DHBV-infected duck model[2]
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Dosage:25-100 mg/kg
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Administration:p.o., for 15 days
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Result:Inhibited DHBV DNA in the sera on day 15.
Chemical Information
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CAS No. 960527-22-4
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Appearance Solid
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Molecular Weight 375.48
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Formula C18H18FN3OS2
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Color White to off-white
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SMILES
O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
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Synonyms
NZ-4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isothiafludine Related Classifications
HY-111003 Related Classifications
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