NEK7
NEK7 is a serine/threonine kinase of the NIMA-related family that acts at the end of the Nek9-Nek6-NEK7 signaling module required for mitotic progression. It is essential for spindle assembly and cytokinesis, functioning downstream of the Nek9 kinase, and its structure reveals a canonical kinase domain in a uniquely autoinhibited conformation. Independently of its enzymatic activity, NEK7 serves as the core scaffold that activates the NLRP3 inflammasome through direct oligomerization-dependent interaction, placing the protein at the intersection of cell division and innate immunity, two intensively targeted arenas.
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NEK7 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
