Raf-1
Raf-1 (CRAF), encoded by RAF1, is the archetypal MAP kinase kinase kinase of the RAS-RAF-MEK-ERK cascade. Recruited to activated RAS at the plasma membrane, Raf-1 undergoes dephosphorylation, dimerization with BRAF and activating phosphorylation before phosphorylating MEK1 and MEK2. Its N-terminal regulatory region binds 14-3-3 proteins and is targeted by phosphorylation events that restrain or release kinase activity. Germline RAF1 mutations cause Noonan syndrome and LEOPARD syndrome, and somatic Raf-1 deregulation contributes to MAPK pathway activation in cancers, sustaining continued pharmacological interest.
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Raf-1 Recombinant Proteins (3)
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Inhibitors & Agonists (51)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
