JNJ-26146900
JNJ-26146900 is a potent and orally active androgen receptor antagonist with a Ki value of 400nM for rat AR. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand. JNJ-26146900 reduces prostate tumor size and prevents bone loss. JNJ-26146900 can be used in research of cancer.
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- CAS No.: 868691-50-3
- Formule: C15H15F3N2O3S
- Masse moléculaire:360.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
JNJ-26146900 bound to the rat androgen receptor transfected into Cos-7 cells with submicromolar potency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
JNJ-26146900 (30-100 mg/kg; p.o.) prevents prostate tumor growth in the Dunning rat model, maximally inhibiting growth at a dose of 10mg/kg. JNJ-26146900 inhibits tumor growth significantly in a CWR22-LD1 mouse xenograft model of human prostate cancer[1].
JNJ-26146900 (30 mg/kg; p.o.; mature male Sprague-Dawley rats) reduces castration-induced tibial bone loss[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mature male Sprague-Dawley rats[1]
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Dosage:10, 30, 100 mg/kg
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Administration:oral gavage; daily, for 6 weeks
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Result:Reduced ventral prostate weight.
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Animal Model:CWR22-LD1 mouse xenograft model[1]
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Dosage:30, 100 mg/kg
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Administration:oral gavage; twice per day for 3 weeks
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Result:Inhibited tumor growth at 100 mg/kg, reducing mean tumor weight at Day 21 to about 30% of the intact vehicle tumor weight.
Chemical Information
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CAS No. 868691-50-3
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Masse moléculaire 360.35
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Formule C15H15F3N2O3S
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SMILES
N#CC1=CC2=C(C=C1C(F)(F)F)NC([C@@](O)(CS(=O)(CC)=O)C)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-26146900 Related Classifications
HY-123310 Related Classifications
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