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Cat. No.: HY-184782

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α-Synuclein-IN-19

α-Synuclein-IN-19 is a polyphenolic acid monoamide derivative and an inhibitor of α-synuclein (α-Syn) aggregation. α-Synuclein-IN-19 can be used in Parkinson's disease-related research.

For research use only. We do not sell to patients.

CAS No.: 1026937-99-4
Formula: C₁₅H₁₄N₂O₃
Molecular Weight:270.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Synuclein-IN-19 Chemical Structure

CAS No.: 1026937-99-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

α-Synuclein-IN-19 is a polyphenolic acid monoamide derivative and an inhibitor of α-synuclein (α-Syn) aggregation. α-Synuclein-IN-19 can be used in Parkinson's disease-related research^[1].

All α-synuclein Isoforms :

In Vitro

α-Synuclein-IN-19 (compound 2e) (30 μM; 72 h) inhibits α-Syn aggregation in vitro with an 88.9% aggregation inhibition ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1026937-99-4
Molecular Weight 270.29
Formula C₁₅H₁₄N₂O₃
SMILES

C(=C/C(NC1=CC=C(N)C=C1)=O)\C2=CC(O)=C(O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. European journal of medicinal chemistry. 2023 Mar 05;249:115122. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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