UPRT - uracil phosphoribosyltransferase homolog Gene

Also Known as UPP; FUR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139596

About UPRT

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:75,156,369-75,304,897 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 3.5), thyroid (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and Cancer. [provided by RefSeq, Nov 2009]

UPRT Products (3)

mRNA Protein Name
NM_001307944.1 NP_001294873.1 uracil phosphoribosyltransferase homolog isoform 2
NM_001363821.1 NP_001350750.1 uracil phosphoribosyltransferase homolog isoform 3
NM_145052.4 NP_659489.1 uracil phosphoribosyltransferase homolog isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPRT Protein Structure

UPRTase

UPRTase: Uracil phosphoribosyltransferase (116 - 294)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

uracil phosphoribosyltransferase homolog

  • RP11-311P8.3

UPRT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Validated Y2H
32296183
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Array
32296183
Intra
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Array
32296183
Intra
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Array
32296183
Intra
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Array
32296183
Intra
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Array
32296183
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
32296183
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Validated Y2H
25416956
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
31515488
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UPRT Proteins

Cat. No. Product Name Accession Purity
HY-P71417 UPRT Protein, Human (His) Q96BW1-1 (M1-D309) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Geotrichosis
Breast Fibrosarcoma

  • Fibrosarcoma Of The Breast
Congenital Toxoplasmosis

  • Toxoplasmosis, Congenital

  • Mother-To-Child Transmission Of Toxoplasmosis

  • Toxoplasma Embryofetopathy

  • Toxoplasma Embryopathy

  • Toxoplasmosis - Congen.

  • Toxoplasmosis Congenital
Coccidiosis

  • Intestinal Coccidiosis

  • Enteric Coccidiosis
Hemophagocytic Lymphohistiocytosis, Familial, 3

  • Familial Hemophagocytic Lymphohistiocytosis 3

  • FHL3

  • Hplh3

  • Hlh3

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Orotic Aciduria

  • Hereditary Orotic Aciduria

  • Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

  • Uridine Monophosphate Synthase Deficiency

  • Umps Deficiency

  • Uridine Monophosphate Synthetase Deficiency

  • Orotic Aciduria I

  • Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

  • Oprt And Odc Deficiency

  • Ump Synthase Deficiency

  • Orotic Aciduria Ii

  • Oroticaciduria 1

  • Orotic Aciduria Hereditary

  • Orotic Aciduria Type 1

  • Hereditary Orotic Aciduria Without Megaloblastic Anemia

  • Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

  • Ump Synthtase Deficiency

  • Umps

  • Orotidylic Decarboxylase Deficiency

  • Orotic Aciduria 1

  • ORAC1

  • Aciduria, Orotic

  • Hereditary Orotic Aciduria, Type 1

  • Orotic Aciduria Nos

  • Orotaciduric Anaemia

  • Orotic Aciduria Anaemia

  • Orotic Aciduria Megaloblastic Anaemia
Cryptosporidiosis

  • Cryptosporidial Gastroenteritis

  • Intestinal Cryptosporidiosis

  • Infection By Cryptosporidium

  • Gastroenteritis Due To Cryptosporidium

  • Cryptosporidial Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15492 UPRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19649 Uprt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26142 Uprt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UPRT VGNC VGNC:48158
Rattus norvegicus UPRT RGD RGD:1564806
Bos taurus UPRT VGNC VGNC:36690
Macaca mulatta UPRT VGNC VGNC:81601
Mus musculus UPRT MGD MGI:2685620
Felis catus UPRT VGNC VGNC:97679
Others UPRT NCBI