2,2'-Bipyridine
Based on 1 publication(s) in Google Scholar
2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 366-18-7
- 分子式: C10H8N2
- 分子量:156.19
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 2,2'-Bipyridine
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Microbiological Assay
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>20 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
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[PMID: 11931621] |
| A2780 | IC50 |
44.8 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
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[PMID: 11931621] |
| CCRF-CEM | IC50 |
51.9 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
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[PMID: 11931621] |
| CCRF-CEM | IC50 |
61.7 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
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[PMID: 11931621] |
| COS-7 | EC50 |
19 μM
Compound: Bip
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Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | EC50 |
34 μM
Compound: Bip
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Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | EC50 |
42 μM
Compound: Bip
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Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
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[PMID: 22957890] |
| COS-7 | IC50 |
126 μM
Compound: Bip
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Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
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[PMID: 22957890] |
| COS-7 | IC50 |
84 μM
Compound: Bip
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Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
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[PMID: 22957890] |
| HUVEC | EC50 |
10 μM
Compound: 2,2'-bipyridine
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Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
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[PMID: 23634668] |
| SK-OV-3 | IC50 |
41.3 μM
Compound: 2,2' bipy
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Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
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[PMID: 11931621] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Holtzman rats (6-8 weeks old)[2].
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Dosage:40 mg/kg
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Administration:Subcutaneous injection; once.
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Result:Showed hyperglycemic activity.
化学情報
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CAS 番号 366-18-7
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性状 Solid
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分子量 156.19
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分子式 C10H8N2
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Color White to light yellow
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SMILES
C1(C2=NC=CC=C2)=NC=CC=C1
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別名
2,2′-ビピリジル
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Photochem Photobiol B
Antimicrobial blue light inactivation of Pseudomonas aeruginosa: Unraveling the multifaceted impact of wavelength, growth stage, and medium composition. [Abstract]2024 Oct:259:113023. PMID: 39241393
2,2'-Bipyridine purchased from MedChemExpress. Usage Cited in: J Photochem Photobiol B. 2024 Oct:259:113023. [Abstract]
Modulation of PAO1 sensitivity to 405 nm aBL in BHI medium with or without FeCl3 supplementation in the presence of the iron chelator 2,2'-Bipyridine (BIP) (500 μM).
溶剤 & 溶解度
DMSO : 100 mg/mL (640.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (481 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4025 mL | 32.0123 mL | 64.0246 mL | 160.0615 mL |
| 5 mM | 1.2805 mL | 6.4025 mL | 12.8049 mL | 32.0123 mL | |
| 10 mM | 0.6402 mL | 3.2012 mL | 6.4025 mL | 16.0061 mL | |
| 15 mM | 0.4268 mL | 2.1342 mL | 4.2683 mL | 10.6708 mL | |
| 20 mM | 0.3201 mL | 1.6006 mL | 3.2012 mL | 8.0031 mL | |
| 25 mM | 0.2561 mL | 1.2805 mL | 2.5610 mL | 6.4025 mL | |
| 30 mM | 0.2134 mL | 1.0671 mL | 2.1342 mL | 5.3354 mL | |
| 40 mM | 0.1601 mL | 0.8003 mL | 1.6006 mL | 4.0015 mL | |
| 50 mM | 0.1280 mL | 0.6402 mL | 1.2805 mL | 3.2012 mL | |
| 60 mM | 0.1067 mL | 0.5335 mL | 1.0671 mL | 2.6677 mL | |
| 80 mM | 0.0800 mL | 0.4002 mL | 0.8003 mL | 2.0008 mL | |
| 100 mM | 0.0640 mL | 0.3201 mL | 0.6402 mL | 1.6006 mL |
2,2'-Bipyridine 関連分類
HY-D0020 関連分類
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