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製品番号: HY-U00086

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Darodipine

(別名: PY 108-068; PY-108068)

Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

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CAS 番号: 72803-02-2
分子式: C₁₉H₂₁N₃O₅
分子量:371.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Darodipine 構造式

CAS 番号: 72803-02-2

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体内実験

Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine^[1]. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 72803-02-2
分子量 371.39
分子式 C₁₉H₂₁N₃O₅
SMILES

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC3=NON=C32)OCC
別名

PY 108-068; PY-108068
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

Animal Administration^[1]

Rats: Male Wistar rats are used. Twelve-month-old rats are left untreated and used as adult reference animals. Twenty-one-month-old rats are allotted randomly to two groups of 8 animals each. Rats of the first group receive an oral daily dose of 5 mg/kg of darodipine in drinking water. The animals of the second group are left untreated and served as a control group. Rats of these two groups are allowed to survive for 6 months, until 27 months of age (old rats). Darodipine-treated rats have water consumption determined every second day and body weight determined weekly^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine(PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78(1):27-37. [Content Brief]

[2]. Vega JA, et al. Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats. Mech Ageing Dev. 1994 Aug;75(2):169-77. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- 体内実験
化学情報
プロトコル
純度とドキュメンテーション
参考文献

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Darodipine

Calcium Channel アイソフォーム固有の製品をすべて表示