Lagociclovir
Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV.
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- CAS 番号: 92562-88-4
- 分子式: C10H12FN5O3
- 分子量:269.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
HBV[1]
体外実験
Lagociclovir (FLG) (6 days) shows inhibitory activity with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM against 3TC-R HBV, wt HBV, PMEA-R HBV and 3TC+PMEA-R HBV, respectively in transiently transfected Huh7 cells[1].
Lagociclovir (0-100 μM; 6 days) inhibits the replication of wild-type and drug-resistant mutants of HBV in transiently transfected Huh7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 92562-88-4
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分子量 269.23
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分子式 C10H12FN5O3
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SMILES
O=C(N=C(N)N1)C2=C1N([C@@H]3O[C@H](CO)[C@@H](F)C3)C=N2
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別名
MIV-210
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lagociclovir 関連分類
HY-14844 関連分類
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