ORL1 antagonist 1
Based on 1 Customer Validation
ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 96.29%
- CAS 番号: 1174985-59-1
- 分子式: C20H22ClN5
- 分子量:367.88
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
IC50: 61 nM (ORL1)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
23 μM
Compound: 17
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Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
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[PMID: 19447610] |
体外実験
ORL1 antagonist 1 is compound 17[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 1174985-59-1
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性状 Solid
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分子量 367.88
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分子式 C20H22ClN5
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Color White to light yellow
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SMILES
CC1=C(C2=CC=CN=C2)N(C3=NC=CC=C3Cl)N=C1CNC4CCCC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 25 mg/mL (67.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7183 mL | 13.5914 mL | 27.1828 mL | 67.9569 mL |
| 5 mM | 0.5437 mL | 2.7183 mL | 5.4366 mL | 13.5914 mL | |
| 10 mM | 0.2718 mL | 1.3591 mL | 2.7183 mL | 6.7957 mL | |
| 15 mM | 0.1812 mL | 0.9061 mL | 1.8122 mL | 4.5305 mL | |
| 20 mM | 0.1359 mL | 0.6796 mL | 1.3591 mL | 3.3978 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0873 mL | 2.7183 mL | |
| 30 mM | 0.0906 mL | 0.4530 mL | 0.9061 mL | 2.2652 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6989 mL | |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3591 mL | |
| 60 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL | 1.1326 mL |
ORL1 antagonist 1 関連分類
HY-112263 関連分類
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