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製品番号: HY-112684

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RO-7

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1370241-45-4
分子式: C₂₄H₂₀F₃N₃O₃S
分子量:487.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

RO-7 構造式

CAS 番号: 1370241-45-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	11.9 μM Compound: 76; RO-7	Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in serum free conditions by CellTiter-Glo luminescent assay	[PMID: 28118010]
MDCK	CC₅₀	86.2 μM Compound: 76; RO-7	Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs in presence of 5 % serum by CellTiter-Glo luminescent assay	[PMID: 28118010]

体外実験

RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

RO-7 protects mice from lethal challenge with both influenza A and B viruses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1370241-45-4
分子量 487.49
分子式 C₂₄H₂₀F₃N₃O₃S
SMILES

O=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jones JC, et al. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation InfluenzaVirus Endonuclease Inhibitors. MBio. 2018 Apr 24;9(2). pii: e00430-18. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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