Antifibrotic agent 3
Antifibrotic agent 3 is an orally active antifibrotic agent. Antifibrotic agent 3 reduces hepatic stellate cell activation by downregulating the expression of Collagen I and α-SMA. Antifibrotic agent 3 inhibits liver fibrosis in bile duct ligation and carbon tetrachloride-induced liver fibrosis models. Antifibrotic agent 3 can be used for the research of liver fibrosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2103516-38-5
- 分子式: C13H13FN2O2
- 分子量:248.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Collagen I |
Antifibrotic agent 3 (10 mg/kg; p.o.; once daily; for 14 consecutive days) reduces CCl4-induced liver injury, collagen deposition, and expression of hepatic fibrosis markers in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6-7 weeks old, 20-22 g, BDL-induced)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Reduced elevated serum ALT, AST, and AKP levels.
Alleviated liver hardening, rough surface, and yellowish spots.
Reduced inflammatory cell infiltration, hepatocyte edema, and necrosis.
Decreased collagen fiber accumulation.
Lowered hepatic hydroxyproline (HYP) levels.
Reduced liver tissue expression of α-SMA and Collagen I.
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Animal Model:C57BL/6J (male, 6-7 weeks old, 20-22 g, CCl4-induced)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Reduced elevated serum ALT and AST levels.
Reduced liver granularity and increased liver glossiness.
Alleviated cellular swelling and inflammatory cell infiltration.
Decreased collagen fiber-stained area.
Lowered hepatic hydroxyproline (HYP) levels.
Reduced liver tissue expression of α-SMA and Collagen I.
化学情報
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CAS 番号 2103516-38-5
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分子量 248.25
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分子式 C13H13FN2O2
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SMILES
COC(C1NCCC2=C1NC3=CC(F)=CC=C32)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antifibrotic agent 3 関連分類
HY-184738 関連分類
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