Apoptosis inducer 17
Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells.
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- CAS 番号: 3126845-21-1
- 分子式: C25H27NO7
- 分子量:453.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) inhibits cell proliferation, with IC50 values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) displays superior inhibition of colony formation. Apoptosis inducer 17 induces dose-dependent G2/M arrest in H446 and H1299 cells[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) induces apoptosis of H446 and H1299 cells is mediated by caspase activity. And also activates JNK signaling cascade[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H446, H1299, and SBC-2 cells
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Concentration:60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
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Incubation Time:72 h
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Result:Effectively inhibited cell proliferation.
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Cell Line:H446, H1299 cells
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Concentration:0.03 μM, 0.1 μM, 0.3 μM
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Incubation Time:24 h
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Result:Induced dose-dependent G2/M arrest.
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Cell Line:H446, H1299 cells
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Concentration:0.03 μM, 0.1 μM, 0.3 μM
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Incubation Time:24 h
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Result:Induced apoptosis of H446 and H1299 cells.
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Cell Line:H446, H1299 cells
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Concentration:0.03 μM, 0.1 μM, 0.3 μM
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Incubation Time:24 h
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Result:Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (4-6 weeks old) injected with H446 cells[1]
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Dosage:10 mg/kg
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Administration:ip; twice a day; for 15 days
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Result:Prevented growth of lung cancer in xenograft tumors.
化学情報
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CAS 番号 3126845-21-1
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分子量 453.48
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分子式 C25H27NO7
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SMILES
O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC/C1=C\C3=CC=C(O)C(OC)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 17 関連分類
HY-163451 関連分類
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