Autoinducing Peptide I
Based on 1 Customer Validation
Autoinducing Peptide I (AIP-I) is a competitive AgrC antagonist and AgrC I activator. By blocking AIP-AgrC interaction and agr quorum sensing signaling, it inhibits MRSA agr-I and agr-III and protects the mouse skin barrier. Autoinducing Peptide I can be used in research on Staphylococcus aureus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.25%
- CAS 番号: 200010-29-3
- 分子式: C43H60N8O13S2
- 分子量:961.11
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Autoinducing Peptide I (AIP-I) inhibits biofilm formation in S. aureus JE2 but not in the agrA mutant JE2 agrA::tn[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 200010-29-3
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性状 Solid
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分子量 961.11
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分子式 C43H60N8O13S2
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Color White to off-white
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別名
AIP-I
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配列
Tyr-Ser-Thr-Cys-Asp-Phe-Ile-Met (Thioester bridge:Cys4-Met8)
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シーケンスの短縮
YSTCDFIM (Thioester bridge:Cys4-Met8)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (104.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0405 mL | 5.2023 mL | 10.4046 mL | 26.0116 mL |
| 5 mM | 0.2081 mL | 1.0405 mL | 2.0809 mL | 5.2023 mL | |
| 10 mM | 0.1040 mL | 0.5202 mL | 1.0405 mL | 2.6012 mL | |
| 15 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL | |
| 20 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3006 mL | |
| 25 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
| 30 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8671 mL | |
| 40 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6503 mL | |
| 50 mM | 0.0208 mL | 0.1040 mL | 0.2081 mL | 0.5202 mL | |
| 60 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4335 mL | |
| 80 mM | 0.0130 mL | 0.0650 mL | 0.1301 mL | 0.3251 mL | |
| 100 mM | 0.0104 mL | 0.0520 mL | 0.1040 mL | 0.2601 mL |
Autoinducing Peptide I 関連分類
HY-P4909 関連分類
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