BA-53038B
Based on 1 Customer Validation
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.73%
- CAS 番号: 2306195-65-1
- 分子式: C14H16ClNO
- 分子量:249.74
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
EC 50: 3.32 μM (HBV)[1]
BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM[1].
BA-53038B has cytotoxicity with CC50 value of >100 μM[1].
BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein[1].
BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly[1].
BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein[1].
BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket[1].
BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML12HBV10 cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Reduced the amount of hypophosphorylated core protein and promoted the assembly of empty capsids with slow electrophoresis mobility.
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Cell Line:AML12HBV10 and HepDES19 cells
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Concentration:0-20 μM
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Incubation Time:2 or 6 days
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Result:Inhibited HBV replication in both AML12HBV10 and HepDES19 cells.
化学情報
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CAS 番号 2306195-65-1
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性状 Solid
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分子量 249.74
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分子式 C14H16ClNO
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Color White to off-white
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SMILES
O=C(NC1=CC=CC(Cl)=C1)C2C3CCCCC32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0042 mL | 20.0208 mL | 40.0416 mL | 100.1041 mL |
| 5 mM | 0.8008 mL | 4.0042 mL | 8.0083 mL | 20.0208 mL | |
| 10 mM | 0.4004 mL | 2.0021 mL | 4.0042 mL | 10.0104 mL | |
| 15 mM | 0.2669 mL | 1.3347 mL | 2.6694 mL | 6.6736 mL | |
| 20 mM | 0.2002 mL | 1.0010 mL | 2.0021 mL | 5.0052 mL | |
| 25 mM | 0.1602 mL | 0.8008 mL | 1.6017 mL | 4.0042 mL | |
| 30 mM | 0.1335 mL | 0.6674 mL | 1.3347 mL | 3.3368 mL | |
| 40 mM | 0.1001 mL | 0.5005 mL | 1.0010 mL | 2.5026 mL | |
| 50 mM | 0.0801 mL | 0.4004 mL | 0.8008 mL | 2.0021 mL | |
| 60 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6684 mL | |
| 80 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.2513 mL | |
| 100 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0010 mL |
BA-53038B 関連分類
HY-114314 関連分類
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