BGM1812
Based on 1 Customer Validation
BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.46%
- 分子式: C182H299N49O61
- 分子量:4149.61
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保管条件:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
BGM1812 (4-fold serial dilutions from 200 μM stock; 1 h) potently activates hAMY3R (EC50 = 0.627 nM) and hCTR (EC50 = 2.270 nM) in HEK-293 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t | AUC0-∞ |
|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | s.c. | 21.1 h | 24 h | 5303 ng/mL | 264931 ng·h/mL | 282265 |
体内実験
BGM1812 (0.012-0.12 mg/kg; subcutaneous injection; once every 3 days; total 10 doses) achieves body weight reduction, dose-dependent weight loss, and favorable body composition changes (increased proportion of lean body mass, decreased fat mass) in diet-induced obesity (DIO) rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 6-8 weeks old, 210-240 g)[1]
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Dosage:1 mg/kg
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Administration:s.c.; single dose
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Result:Had a sustained inhibitory effect on food intake, significantly reducing food intake 3-4 days after administration.
Reduced body weight, demonstrating a sustained weight loss advantage.
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Animal Model:Sprague-Dawley (male, 20 weeks old, diet-induced obesity model)[1]
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Dosage:0.012 mg/kg; 0.04 mg/kg; 0.12 mg/kg
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Administration:s.c.; every third day; 10 doses
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Result:Reduced weight and food intake, increased lean body mass, and reduced fat mass.
化学情報
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性状 Solid
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分子量 4149.61
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分子式 C182H299N49O61
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Color White to off-white
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配列
{γGlu-C20 diacid}-Arg-Asp-Gly-Thr-Ala-Thr-Lys-Ala-Thr-Glu-Arg-{αMeLeu}-Ala-{Aad}-Phe-Leu-Gln-Arg-Ser-Ser-Phe-{Sar}-Ala-{Sar}-Leu-Ser-Ser-Thr-Glu-Thr-Gly-Ser-Asn-Thr-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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シーケンスの短縮
{γGlu-C20 diacid}-RDGTATKATER-{αMeLeu}-A-{Aad}-FLQRSSF-{Sar}-A-{Sar}-LSSTETGSNT-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (24.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (297 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2410 mL | 1.2049 mL | 2.4099 mL | 6.0247 mL |
| 5 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2049 mL | |
| 10 mM | 0.0241 mL | 0.1205 mL | 0.2410 mL | 0.6025 mL | |
| 15 mM | 0.0161 mL | 0.0803 mL | 0.1607 mL | 0.4016 mL | |
| 20 mM | 0.0120 mL | 0.0602 mL | 0.1205 mL | 0.3012 mL |
BGM1812 関連分類
HY-P11587 関連分類
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