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製品番号: HY-123560

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BKM-570

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 259885-54-6
分子式: C₃₄H₃₄Cl₂F₅N₃O₃
分子量:698.55

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BKM-570 構造式

CAS 番号: 259885-54-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer^[1].

Bradykinin Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	4 μM Compound: BKM-570	Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against rat C6 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Cancer cell lines	IC₅₀	1.8 μM Compound: BKM-570	Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Small cell lung cancer cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
Granta	IC₅₀	63.3 μM Compound: BKM-570	Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Granta cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
HEK293	IC₅₀	3.8 μM Compound: BKM-570	Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HEK293 cells overexpressing CHI3L1 gene assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
JeKo-1	IC₅₀	49.3 μM Compound: BKM-570	Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human Jeko cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]
U-373MG ATCC	IC₅₀	3.3 μM Compound: BKM-570	Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 25012567]

化学情報

CAS 番号 259885-54-6
分子量 698.55
分子式 C₃₄H₃₄Cl₂F₅N₃O₃
SMILES

O=C([C@@H](NC(/C=C/C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC2=CC=C(C=C2)OCC3=C(C=CC=C3Cl)Cl)NC4CC(C)(C)NC(C)(C)C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Stephanie Jutras, et al. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec;277(24):5146-60. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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BKM-570

Bradykinin Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

BKM-570 関連分類

HY-123560 関連分類