Butibufen
Based on 1 Customer Validation
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.91%
- CAS 番号: 55837-18-8
- 分子式: C14H20O2
- 分子量:220.31
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保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Orally Active Compound Library
HY-L061
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Metabolism/Protease Compound Library
HY-L012
生物活性
Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose[2]. Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure[2]. Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes[2]. Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepatocytes from Sprague-Dawley male rats
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Concentration:0.1 μM-0.1 M
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Incubation Time:60 min
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Result:Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[3]
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Dosage:50 and 250 mg/kg
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Administration:Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice
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Result:Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
化学情報
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CAS 番号 55837-18-8
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性状 Solid-Liquid Mixture
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分子量 220.31
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分子式 C14H20O2
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SMILES
CCC(C(O)=O)C1=CC=C(C=C1)CC(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
参考文献
[1]. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41. [Content Brief]
[2]. Castell JV, et al. A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica. 1988 Jun;18(6):737-45. [Content Brief]
[3]. Alamo C, et al. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Butibufen 関連分類
HY-121132 関連分類
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