Caged MK801
Caged MK801 is a photolabile NMDA receptor open-channel blocker. Caged MK801 releases MK801 upon photolysis activation, producing use-dependent blockade of NMDA receptor currents and synaptic NMDA receptor-mediated currents. Caged MK801 releases MK801 by photolysis in the postsynaptic region (somatodendritic region), which blocks the induction of timing-dependent long-term potentiation (t-LTP). Caged MK801 can be used in research related to neurological diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 217176-91-5
- 分子式: C26H24N2O6
- 分子量:460.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
NMDA Receptor |
体外実験
Caged MK801 (1 mM; axonal UV flash) blocks t-LTD induction in paired L4-L2/3 recordings, whereas soma-dendritic flash does not block t-LTD[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 217176-91-5
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分子量 460.48
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分子式 C26H24N2O6
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SMILES
COC(C=C1COC(N2[C@@H]3CC4=C([C@]2(C)C5=CC=CC=C53)C=CC=C4)=O)=C(C=C1[N+]([O-])=O)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rodríguez-Moreno A, et al. Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jun 08;31(23):8564-8569. [Content Brief]
[2]. Reeve JE, et al. Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative & integrative biology. 2012 May 01;5(3):240-2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Caged MK801 関連分類
HY-164264 関連分類
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