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製品番号: HY-122045

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CB 3705

CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID₅₀s of 4.77 μM and 408 μM, respectively.

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CAS 番号: 5854-11-5
分子式: C₂₁H₂₁N₅O₆
分子量:439.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CB 3705 構造式

CAS 番号: 5854-11-5

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	2.7 μM Compound: 5,8-deazafolate	Ability to inhibit thymidylate synthase derived from human leukemia K562 cells Ability to inhibit thymidylate synthase derived from human leukemia K562 cells	[PMID: 3470522]
L1210	IC₅₀	0.1 mM Compound: table II	Evaluated for the inhibition of thymidylate synthase in intact L1210 cells Evaluated for the inhibition of thymidylate synthase in intact L1210 cells	[PMID: 3599032]
L1210	IC₅₀	1.00E-05 M Compound: table II	Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cells Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cells	[PMID: 3599032]

化学情報

CAS 番号 5854-11-5
分子量 439.42
分子式 C₂₁H₂₁N₅O₆
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC3=C(NC(N)=NC3=O)C=C2)C=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Calvert AH, et al. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer (1965). 1980 May;16(5):713-22. [Content Brief]

[2]. Jackman AL, et al. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies. Cancer Res. 1986 Jun;46(6):2810-5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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