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製品番号: HY-118018

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CHF-2993

CHF-2993 is an orally active anticonvulsant. CHF-2993 antagonizes Bicuculline (HY-N0219)- and Picrotoxin (HY-101391)-induced tonic convulsions in mice, shows no activity against Pentylenetetrazole-induced clonic convulsions in mice, and partially reduces Veratridine (HY-N6691)-induced aspartate efflux in rat cortical synaptosomes. CHF-2993 can be used in the research of epilepsy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 202914-21-4
分子式: C₁₂H₁₆N₂O₂
分子量:220.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CHF-2993 構造式

CAS 番号: 202914-21-4

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

CHF-2993 (Compound 49) (multiple administrations; oral administration) exhibits anticonvulsant activity against maximal electroshock-induced tonic seizures in male CD-1 mice, with an oral ED₅₀ of 36 mg/kg and low neurotoxicity (TD₅₀ = 1172 mg/kg)^[1].
CHF-2993 (multiple administrations; oral administration) antagonizes bicuculline-induced tonic seizures in male CD-1 mice, with an oral ED₅₀ of 65 mg/kg^[1].
CHF-2993 (multiple administrations; oral administration) exerts a protective effect against picrotoxin-induced tonic convulsions in male CD-1 mice, with an oral ED₅₀ of 14 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 202914-21-4
分子量 220.27
分子式 C₁₂H₁₆N₂O₂
SMILES

N([C@H](C(N)=O)CO)C1CC=2C(C1)=CC=CC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ghidini E, et al. Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives. Bioorg Med Chem. 2006;14(10):3263-3274. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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