CI-1029
CI-1029 is a HIV-1 protease inhibitor with a human IC50 of 0.11 nM. CI-1029 inhibits both wild-type and mutant HIV proteases, and exhibits antiviral activity against HIV and multiple drug-resistant HIV strains, with an EC50 of 6.31 μM in the presence of 30% human serum. CI-1029 can be used in studies related to HIV infection and acquired immunodeficiency syndrome (AIDS).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 207736-05-8
- 分子式: C28H37NO4S
- 分子量:483.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HIV-1 Protease 0.11 nM (IC50) |
CI-1029 (60 min) potently inhibits purified HIV-1 protease with an IC50 of 0.11 nM and a Ki of 0.11 nM[1].
CI-1029 protects HIV-IIIB-infected CEM cells with an EC50 of 0.20 μM and has low cytotoxicity in uninfected CEM cells with a TC50 of 210 μM, yielding a therapeutic index of 1000[1].
CI-1029 protects HIV-infected cells in the presence of 30% human serum with an EC50 of 6.31 μM[1].
CI-1029 retains potent activity against multiple protease-resistant HIV strains in PBMCs, with a fold increase in EC50 of ≤2 compared to wild-type virus[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 207736-05-8
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分子量 483.66
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分子式 C28H37NO4S
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SMILES
NC(C=C1)=CC=C1CC[C@]2(CC(O)=C(C(O2)=O)SC3=C(C=C(C(C)=C3)CO)C(C)(C)C)C(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CI-1029 関連分類
HY-114957 関連分類
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