Complement C1s-IN-1
Based on 1 Customer Validation
Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.77%
- CAS 番号: 3033831-40-9
- 分子式: C22H20F2N6O
- 分子量:422.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 36 nM (C1s)[1]
Pharmacokinetic Parameters of Complement C1s-IN-1 in Male C57BL/6J mice[1].
| Dosage (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUC(0-24h) (h* ng/mL) | MRT (h) |
| 10 | 1032.5±173.0 | 1.67±0.58 | 6017.8±390.4 | 4.31±0.23 |
| 30 | 2583.3±267.1 | 2.67±1.15 | 21928.6±1428.2 | 5.02±0.18 |
| 100 | 8895.9±1516.8 | 4.00±0.00 | 13934.1±36760.1 | 7.66±0.99 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice[1]
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Dosage:10, 30, 100 mg/kg
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Administration:P.o.
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Result:Significantly inhibited MAC formation induced by human serum in a dose-dependent manner.
化学情報
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CAS 番号 3033831-40-9
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性状 Solid
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分子量 422.43
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分子式 C22H20F2N6O
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Color Off-white to light yellow
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SMILES
NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Complement C1s-IN-1 関連分類
HY-149278 関連分類
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