Complex 3
Complex 3 is a fluorescent dithiocarbazate-copper complex with anticancer activity, which localizes to mitochondria. Complex 3 displays excitation/emission maxima of 455-495/535 nm, respectively. Complex 3 inhibits the growth of BxPC-3, AsPC-1, PANC-1, and WI38 pancreatic cancer cells with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Complex 3 induces lipid peroxidation and mitochondrial rupture and shrinkage in AsPC-1 cells. Complex 3 also induces mitochondrial apoptosis and cytokine-cytokine receptor interaction dysfunction in AsPC-1 cells. Complex 3 reduces tumor volume in an AsPC-1 mouse xenograft model.
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- CAS 番号: 2480150-28-3
- 分子式: C26H22Br3Cu3N8S4
- 分子量:1005.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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生物活性
製品説明
化学情報
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CAS 番号 2480150-28-3
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分子量 1005.12
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分子式 C26H22Br3Cu3N8S4
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SMILES
[Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Complex 3 関連分類
HY-158726 関連分類
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