CU-CPD107
Based on 1 Customer Validation
CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.07%
- CAS 番号: 2573912-32-8
- 分子式: C16H21IN2O2
- 分子量:400.25
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7 μM[1].
CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA[1].
CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2573912-32-8
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性状 Solid
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分子量 400.25
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分子式 C16H21IN2O2
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Color White to off-white
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SMILES
IC1=C(C2=CC=CC=C2)N(CC(C)(C)O)C(COCC)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (312.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4984 mL | 12.4922 mL | 24.9844 mL | 62.4610 mL |
| 5 mM | 0.4997 mL | 2.4984 mL | 4.9969 mL | 12.4922 mL | |
| 10 mM | 0.2498 mL | 1.2492 mL | 2.4984 mL | 6.2461 mL | |
| 15 mM | 0.1666 mL | 0.8328 mL | 1.6656 mL | 4.1641 mL | |
| 20 mM | 0.1249 mL | 0.6246 mL | 1.2492 mL | 3.1230 mL | |
| 25 mM | 0.0999 mL | 0.4997 mL | 0.9994 mL | 2.4984 mL | |
| 30 mM | 0.0833 mL | 0.4164 mL | 0.8328 mL | 2.0820 mL | |
| 40 mM | 0.0625 mL | 0.3123 mL | 0.6246 mL | 1.5615 mL | |
| 50 mM | 0.0500 mL | 0.2498 mL | 0.4997 mL | 1.2492 mL | |
| 60 mM | 0.0416 mL | 0.2082 mL | 0.4164 mL | 1.0410 mL | |
| 80 mM | 0.0312 mL | 0.1562 mL | 0.3123 mL | 0.7808 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2498 mL | 0.6246 mL |
CU-CPD107 関連分類
HY-147310 関連分類
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