DBCO-PEG3-AP1867
DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C65H78N4O15
- 分子量:1155.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
DBCO-PEG3-AP1867 successfully undergoes SPAAC reaction with azide-modified c-Myc-binding oligonucleotides to form a bifunctional OGTAC construct targeting c-Myc[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) potently induces O-GlcNAcylation of c-Myc and the proximity interaction between c-Myc and OGT in HEK293T-fOGT cells overexpressing Flag-c-Myc[1].
DBCO-PEG3-AP1867-derived OGTAC (0.1-5 μg/mL; 24 h) significantly reduces the viability of HeLa-fOGT cells[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) remodels the genomic occupancy of c-Myc and significantly downregulates MALAT1 expression in a c-Myc O-GlcNAcylation-dependent manner in HeLa-fOGT cells and HEK293T-fOGT cells overexpressing c-Myc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1155.33
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分子式 C65H78N4O15
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SMILES
COC(C=C1)=C(OC)C=C1CC[C@@H](OC([C@H]2N(C([C@@H](CC)C3=CC(OC)=C(OC)C(OC)=C3)=O)CCCC2)=O)C4=CC(OCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O)=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DBCO-PEG3-AP1867 関連分類
HY-184176 関連分類
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