DM1-PEG4-DBCO
Based on 1 Customer Validation
DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.11%
- 分子式: C63H80ClN5O16
- 分子量:1198.79
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
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Maytansinoids |
化学情報
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性状 Solid
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分子量 1198.79
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分子式 C63H80ClN5O16
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Color Off-white to light yellow
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SMILES
COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(O[C@@]([C@@H](C)[C@@](O3)([H])[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (83.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (249 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8342 mL | 4.1709 mL | 8.3417 mL | 20.8544 mL |
| 5 mM | 0.1668 mL | 0.8342 mL | 1.6683 mL | 4.1709 mL | |
| 10 mM | 0.0834 mL | 0.4171 mL | 0.8342 mL | 2.0854 mL | |
| 15 mM | 0.0556 mL | 0.2781 mL | 0.5561 mL | 1.3903 mL | |
| 20 mM | 0.0417 mL | 0.2085 mL | 0.4171 mL | 1.0427 mL | |
| 25 mM | 0.0334 mL | 0.1668 mL | 0.3337 mL | 0.8342 mL | |
| 30 mM | 0.0278 mL | 0.1390 mL | 0.2781 mL | 0.6951 mL | |
| 40 mM | 0.0209 mL | 0.1043 mL | 0.2085 mL | 0.5214 mL | |
| 50 mM | 0.0167 mL | 0.0834 mL | 0.1668 mL | 0.4171 mL | |
| 60 mM | 0.0139 mL | 0.0695 mL | 0.1390 mL | 0.3476 mL | |
| 80 mM | 0.0104 mL | 0.0521 mL | 0.1043 mL | 0.2607 mL |
DM1-PEG4-DBCO 関連分類
HY-136261 関連分類
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