Ferfluor-1
Based on 1 Customer Validation
Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 3030473-59-4
- 分子式: C15H20N4S
- 分子量:288.41
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ferfluor-1 potently inhibits ferroptosis in HT1080 fibrosarcoma cells with an EC50 of 57 nM, in OS-RC-2 renal carcinoma cells with an EC50 of 75 nM, and in SH-SY5Y neuroblastoma cells with an EC50 of 2.3 nM[1].
Ferfluor-1 (5 μM) does not inhibit Staurosporine (HY-15141)-induced apoptosis in SH-SY5Y neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male)[1]
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Dosage:10 mg/kg
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Administration:i.v.; single administration
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Result:Substantially decreased cerebral infarction volume compared to the vehicle control.
Reduced the proportion of infarcted tissue compared to the vehicle control.
Improved blood flow in ischemic brain tissue compared to the vehicle control.
Significantly decreased PTGS2 gene expression in the lesioned hemisphere compared to the vehicle control.
Reduced malondialdehyde (MDA) levels in the lesioned hemisphere relative to the vehicle control.
Showed no obvious toxicity in major organs (heart, liver, spleen, lung, kidney) via histopathological staining.
化学情報
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CAS 番号 3030473-59-4
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性状 Solid
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分子量 288.41
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分子式 C15H20N4S
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Color Light yellow to yellow
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SMILES
NC1=C(NC2CCCCC2)C=CC(C3=NN=C(C)S3)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : ≥ 250 mg/mL (866.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4673 mL | 17.3364 mL | 34.6729 mL | 86.6822 mL |
| 5 mM | 0.6935 mL | 3.4673 mL | 6.9346 mL | 17.3364 mL | |
| 10 mM | 0.3467 mL | 1.7336 mL | 3.4673 mL | 8.6682 mL | |
| 15 mM | 0.2312 mL | 1.1558 mL | 2.3115 mL | 5.7788 mL | |
| 20 mM | 0.1734 mL | 0.8668 mL | 1.7336 mL | 4.3341 mL | |
| 25 mM | 0.1387 mL | 0.6935 mL | 1.3869 mL | 3.4673 mL | |
| 30 mM | 0.1156 mL | 0.5779 mL | 1.1558 mL | 2.8894 mL | |
| 40 mM | 0.0867 mL | 0.4334 mL | 0.8668 mL | 2.1671 mL | |
| 50 mM | 0.0693 mL | 0.3467 mL | 0.6935 mL | 1.7336 mL | |
| 60 mM | 0.0578 mL | 0.2889 mL | 0.5779 mL | 1.4447 mL | |
| 80 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0835 mL | |
| 100 mM | 0.0347 mL | 0.1734 mL | 0.3467 mL | 0.8668 mL |
Ferfluor-1 関連分類
HY-185056 関連分類
Powered by Bioz
- Ferfluor-1
- 3030473-59-4
- Ferfluor1
- Ferfluor 1
- Ferroptosis
- Fluorescent Dye
- phospholipid peroxidation
- OS-RC-2 renal carcinoma cells
- ferroptosis
- phospholipid hydroperoxides
- Parkinson’s disease
- HT1080 fibrosarcoma cells
- stroke
- blood-brain barrier
- SH-SY5Y neuroblastoma cells
- endoplasmic reticulum
- Inhibitor
- inhibitor
- inhibit