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United States

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製品番号: HY-172934

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FGT-4

FGT-4 is a FR-β-targeted chimeric molecule. FGT-4 acts as a TLR7 agonist. FGT-4 binds to FR-β to enable delivery to tumor-associated macrophages and myeloid-derived suppressor cells. FGT-4 promotes the secretion of iNOS (associated with M1 macrophages) and the pro-inflammatory cytokine IL-6, and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 can be used for the research of breast cancer.
(Pink: TLR7 ligand (HY-103698); Blue: FR-β ligand (HY-172935); Black: linker (HY-172936)).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₅₀H₅₇N₁₁O₉S₂
分子量:1020.19

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

FGT-4 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

FGT-4 is a FR-β-targeted chimeric molecule. FGT-4 acts as a TLR7 agonist. FGT-4 binds to FR-β to enable delivery to tumor-associated macrophages and myeloid-derived suppressor cells. FGT-4 promotes the secretion of iNOS (associated with M1 macrophages) and the pro-inflammatory cytokine IL-6, and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 can be used for the research of breast cancer^[1]. (Pink: TLR7 ligand (HY-103698); Blue: FR-β ligand (HY-172935); Black: linker (HY-172936)).

IC₅₀ & Target^[1]

FR-β

TLR7

IL-6

iNOS

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示 :

NO Synthase アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

FGT-4 (24 h) exhibits minimal cytotoxicity to 4T1 breast cancer cells and HUVEC cells across a broad concentration range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

FGT-4 (1 mg/kg; i.v.; daily; 14 days) inhibits 4T1 tumor growth, reprograms tumor-associated macrophages to a pro-inflammatory phenotype, reshapes the tumor immune microenvironment, extends mouse survival to 35 days, and exhibits no apparent systemic toxicity^[1].
FGT-4 (20 μg; s.c.; single dose) does not induce elevated pro-inflammatory cytokine levels in healthy mice, demonstrating improved safety compared to free IMDQ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 6 weeks old, orthotopic 4T1 tumor model, fed 2-week folate-deficient diet)^[1]
Dosage:

1 mg/kg
Administration:

i.v.; daily; 14 days
Result:

Reduced tumor growth compared to control group, with final tumor weights lower than control.
Increased the M1/M2 macrophage ratio in tumor tissues.
Decreased the proportion of Ly6C⁺ and Ly6G⁺ myeloid-derived suppressor cells within CD45⁺ cells.
Upregulated the percentage of CD8⁺ T cells in tumors.
Extended mouse survival to 35 days.
Caused no significant changes in mouse body weight during treatment.
Detected no pathological alterations in heart, liver, spleen, or kidney tissues.

Animal Model:

BALB/c (female, 6 weeks old)^[1]
Dosage:

20 μg
Administration:

s.c.; single dose
Result:

Did not trigger increased plasma levels of TNF-α or IL-6.

化学情報

分子量 1020.19
分子式 C₅₀H₅₇N₁₁O₉S₂
SMILES

NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CSSCCOC(NCC4=CC=C(CN5C6=C7C=CC=CC7=NC(N)=C6N=C5CCCC)C=C4)=O)=O)=O)N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Guo L, et al. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines as Targeting Ligands. J Med Chem. 2025 Apr 24;68(8):8295-8309. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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FGT-4

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示

NO Synthase アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示