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製品番号: HY-182445

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FPL 66564

FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness.

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CAS 番号: 140369-78-4
分子式: C₈H₁₄O₄S₂
分子量:238.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPL 66564 構造式

CAS 番号: 140369-78-4

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価格（税別）

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数量

Sample (0.1mg)

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

ACE

5.7 nM (IC₅₀)

体外実験

FPL 66564 is degraded in human blood with a half-life of 14 minutes to form inactive, small hydrophilic products^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

FPL 66564 (100-1000 nmoL/kg/min; i.v.; continuous infusion) rapidly achieves sustained, dose-dependent inhibition of angiotensin I pressor responses in urethane-anesthetized rats, with effects that rapidly dissipate after infusion cessation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat (anesthetized with urethane)^[2]
Dosage:

100 nmol/kg/min; 300 nmol/kg/min; 1000 nmol/kg/min
Administration:

i.v.; continuous infusion
Result:

Achieved rapid equilibrium of pressor response inhibition, followed by a sustained plateau.
Maintained ~90-95% inhibition of pressor response during infusion at 1000 nmol/kg/min dose.
Maintained ~75-80% inhibition during infusion at 300 nmol/kg/min dose.
Maintained ~60-65% inhibition during infusion at 100 nmol/kg/min dose.
Rapidly dissipated inhibitory effect on cessation of infusion, with all groups returning to near-baseline levels of inhibition (≤25%) by 60 minutes post-infusion.

化学情報

CAS 番号 140369-78-4
分子量 238.32
分子式 C₈H₁₄O₄S₂
SMILES

SC[C@@H](C)C(O[C@H](C(O)=O)CSC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bodor N, et al. Soft drug design: general principles and recent applications. Med Res Rev. 2000;20(1):58-101. [Content Brief]

[2]. Baxter AJ, et al. (R)-2-(3-mercapto-2 (S)-methyl-1-oxopropoxy)-3-(methylthio) propanoic acid (FPL 66564), the first ultra-short-acting angiotensin converting enzyme inhibitor. Journal of medicinal chemistry. 1992 Oct;35(20):3718-20.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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